SAFEGUARD MICROPLEX BLOOD PANEL
Safeguard Microplex Blood Panel
The Safeguard Microplex Blood Panel offers several advantages to classical blood cultures, with rapid and more accurate identifications, including fastidious and slow-growing organisms. It also offers detection of a wider population of bacteria than other molecular products available as clinical diagnostics and is significantly less expensive.
Safeguard Microplex Blood Panel is a qualitative multiplexed nucleic acid-based in vitro diagnostic test intended for the simultaneous detection and identification of multiple bacterial nucleic acids from Gram-positive and Gram-negative organisms in whole blood from patients presenting with symptoms of bacteremia or Candidemia, all-in-one reaction.
The test involves cell lysis, DNA extraction, PCR amplification and hybridization on a microarray. Results are analyzed from fluorescent signals representing specific DNA probes to identify 54 microorganisms in a single hybridization. After detection and identification in the Microarray, a reflex test of Antibiotic Resistance Genes can be performed on the same extracted DNA.
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MICROPLEX BLOOD PANEL
CONVENTIONAL BLOOD CULTURE
DNA Isolation: 2-3 hours
PCR Amplification: 2-3 hours
Pathogen Identification: 1-2 hours
Antibiotic resistance testing: 2-3 hours
Bacterial culture: 24-72 hours
Identification: 4 -24 hours
Antibiotic susceptibility testing: 24 hours
20 - 40 mL
Not time and temperature sensitive
Time and temperature sensitive
DETECTION OF PATHOGEN
(detects dead or live microorganisms)
(detects live microorganisms only)
Benefits of the Safeguard Microplex Blood Panel
10-12 hours turn-around-time
High sensitivity & specificity of test
Test cost is the same or lower to culture system
DNA isolation from 3mL of whole blood
Culture is not required
Multiple infections can be detected in the same specimen
Antibiotic Resistance Genes will be identified if pathogens are detected
Capacity per run: 86 samples
Detects pathogens “dead or alive”
Sample integrity is preserved from point of draw
Detects difficult-to-grow bacteria and yeast