SAFEGUARD MICROPLEX BLOOD PANEL

Safeguard Microplex Blood Panel

The Safeguard Microplex Blood Panel offers several advantages to classical blood cultures, with rapid and more accurate identifications, including fastidious and slow-growing organisms. It also offers detection of a wider population of bacteria than other molecular products available as clinical diagnostics and is significantly less expensive.

Safeguard Microplex Blood Panel is a qualitative multiplexed nucleic acid-based in vitro diagnostic test intended for the simultaneous detection and identification of multiple bacterial nucleic acids from Gram-positive and Gram-negative organisms in whole blood from patients presenting with symptoms of bacteremia or Candidemia, all-in-one reaction.

The test involves cell lysis, DNA extraction, PCR amplification and hybridization on a microarray. Results are analyzed from fluorescent signals representing specific DNA probes to identify 54 microorganisms in a single hybridization.  After detection and identification in the Microarray, a reflex test of Antibiotic Resistance Genes can be performed on the same extracted DNA.

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Comparative

MICROPLEX BLOOD PANEL

CONVENTIONAL BLOOD CULTURE

TURNAROUND TIME

DNA Isolation: 2-3 hours

PCR Amplification: 2-3 hours

Pathogen Identification: 1-2 hours

Antibiotic resistance testing: 2-3 hours

10-12 HOURS

2-5 DAYS

Bacterial culture: 24-72 hours

Identification: 4 -24 hours

Antibiotic susceptibility testing: 24 hours

ACCURACY

98+%

65%

SAMPLE VOLUME

3 mL

20 - 40 mL

STABILITY

Not time and temperature sensitive

Time and temperature sensitive

DETECTION OF PATHOGEN

DNA based

(detects dead or live microorganisms)

Culture based

(detects live microorganisms only)

Benefits of the Safeguard Microplex Blood Panel

10-12 hours turn-around-time

High sensitivity & specificity of test

Test cost is the same or lower to culture system

DNA isolation from 3mL of whole blood

Culture is not required

Multiple infections can be detected in the same specimen

Antibiotic Resistance Genes will be identified if pathogens are detected

Capacity per run: 86 samples

Detects pathogens “dead or alive”

Sample integrity is preserved from point of draw

Detects difficult-to-grow bacteria and yeast

© 2020 Safeguard DNA Diagnostic Inc. All Rights Reserved

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Unit 103, G Business Hub Bldg.728 Shaw Boulevard, Mandaluyong City Metro Manila, Philippines

Tel: (02) 296-7595

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